Nick velayati biography

ABSTRACT

Moxifloxacin is central to treatment of multidrug-resistant tuberculosis. Effects of moxifloxacin on the Mycobacterium tuberculosis redox state were explored to identify strategies for increasing lethality and reducing the prevalence of extensively resistant tuberculosis. A noninvasive redox biosensor and a reactive oxygen species (ROS)-sensitive dye revealed that moxifloxacin induces oxidative stress correlated with M. tuberculosis death. Moxifloxacin lethality was mitigated by supplementing bacterial cultures with an ROS scavenger (thiourea), an iron chelator (bipyridyl), and, after drug removal, an antioxidant enzyme (catalase). Lethality was also reduced by hypoxia and nutrient starvation. Moxifloxacin increased the expression of genes involved in the oxidative stress response, iron-sulfur cluster biogenesis, and DNA repair. Surprisingly, and in contrast with Escherichia coli studies, moxifloxacin decreased expression of genes involved in respiration, suppressed oxygen consumption, increased the NADH/NAD⁺ ratio, and increased the labile iron pool in M. tuberculosis. Lowering the NADH/NAD⁺ ratio in M. tuberculosis revealed that NADH-reductive stress facilitates an iron-mediated ROS surge and moxifloxacin lethality. Treatment with N-acetyl cysteine

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The 2013 Presidential Election: 686 Applicants, Only Eight Contenders

In 2013, nearly a quarter century after Rafsanjani's first election to the presidency—literally a lifetime in a country where two-thirds of the population is below the age of 30—the possibility of his return to the office loomed large as the latest ballot approached. He had already served two terms, from 1989 to 1997, and had sought a third in 2005, in a tight race against Mahmoud Ahmadinejad, then mayor of Tehran. He lost that contest in a run-off, a defeat that stung the establishment and catapulted the little-known Ahmadinejad into the limelight. Ahmadinejad's presidency reversed the trajectory of Iran's post-war path of moderation, and put the revolution back on a collision course with the international community.

600 hopefuls, 8 nominees, 1 president…Winners, losers and how it all worked.Breaking down Iran's 2013 presidential election…in less than two minutes.
Brianne M. Aiken

This time around, after months of public vacillation, Rafsanjani arrived to register his candidacy at the last possible moment, creating a perfectly orchestrated election surprise. His dramatic bid captivated an Iranian political establishment that had been in a state of suspended animation for four years

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