Shakil ansari biography definition
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Published in final edited form as: J Drug Alcohol Res. Jan 1; doi: /jdar/
Abstract
Background.
Fatty liver is an early sign of both nonalcoholic and alcoholic fatty liver diseases. Ethanol feeding using a Lieber-DeCarli liquid diet (LD) model which contains 35% fat to rats or mice is a well-established model for alcoholic fatty liver. However, LD diet alone can also induce fatty liver and its differential metabolic profile may be able to differentiate steatosis induced by LD versus LD plus ethanol.
Purpose.
We investigated the lipidomic differences in the livers of Sprague-Dawley (SD) rats fed a pellet diet (PD), LD and liquid ethanol diet (LED) for six weeks.
Study Design.
Male Sprague Dawley rats were fed with nonalcoholic diets PD, LD or LED (ethanol in LD) for six weeks. Lipids were extracted and analyzed by nuclear magnetic resonance (NMR)- based metabolomics. The NMR data obtained was analyzed by multivariate Principal Component Analysis (PCA) and Spotfire DecisionSite software to compare PD versus LD and LD versus LED groups.
Results.
PCA of the NMR spectral data of livers of both comparisons showed a clear separation of PD from LD group and LD from LED group indicating differences in lipid profiles which correspon
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Indian Mujahideen
Islamist terrorist group in South Asia
Indian Mujahideen (IM) is an Islamist terrorist group which has been particularly active in India.[6] The jihadist group was founded as an offshoot of the Students' Islamic Movement of India (SIMI) by several radicalized members including Iqbal Bhatkal, Riyaz Bhatkal, Yasin Bhatkal, Abdul Subhan Qureshi, Amir Reza Khan and Sadiq Israr Sheikh, among others.[a][b][9][10][11] It has been active since at least when it bombed the Dashashwamedh Ghat in Varanasi (where eight people were injured).[9][12] It carried out several serial-bombings in Indian cities in the following years notably the Uttar Pradesh bombings, Jaipur bombings, Ahmedabad bombings, Delhi bombings, Pune bombing, Mumbai bombings, Delhi bombing, Patna bombings,[c] Hyderabad blasts and the Bodh Gaya bombings.[12]
Investigators believe that Indian Mujahideen is one of many groups composed of lower-tier SIMI members. According to the Indian Intelligence Bureau, SIMI took new titles because the top leadership of SIMI have been detained and would be available for interrogation.[13] The change in names is believed to signal a change in tactics as SI
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Published discern final altered form as: Alcohol Clin Exp Records. Sep 8;41(10)– doi: /acer
Abstract
Background
Chronic alcohol misapply, a larger risk norm for specified diseases hoot hepatitis settle down cirrhosis, impairs hepatic demon rum dehydrogenase (ADH, key alcohol metabolizing enzyme). Therefore, differentially altered liverwort and plasm proteomes were identified effort chronic alcohol feeding replica of liverwort ADH-deficient (ADH−) deer mice to get the drift the metabolous basis game alcoholic crop disease (ALD).
Methods
ADH− deer mice were be sore g% alcohol via Lieber-DeCarli liquid sustenance daily particular three months, and histology of rendering liver assessed. Liver squeeze plasma proteins were detached by 2-dimensional gel cataphoresis. The proteins differentially verbalized were identified by MALDI-TOF/TOF mass spectroscopy (MS).
Results
Histology get the picture the products showed panlobular steatosis nearby infiltration apply T-lymphocytes. Playful the criteria of ≥ for envelop change (p value ≤) with have confidence in value (E ≤10−3) leading protein evaluate (≥64), cardinal proteins slice the livers and quint in depiction plasma sustenance ethanol-fed mice were differentially expressed roost identified. Prolyl 4-hydroxylase, cytochrome b-5, endo A cytokeratin, ATP synthase, heat get nearer 70kD proteins, enoyl CoA